Wenjun Zhou Martini

EDUCATION
1984, Chemical Engineering, B.S. -Zhejiang Institute of Technology, Hangzhou, China
1987, Chemical Engineering, M.S. -Zhejiang University, Hangzhou, China
1998, Nutrition and Physiology, Ph.D. -University of Texas Medical Branch, Galveston, TX, USA

ORGANIZATION
American Physiological Society and SHOCK Society

RESEARCH AND PROFESSIONAL EXPERIENCE
1/2003- Present Research Physiologist, U.S. Army Institute of Surgical Research, Ft. Sam Houston, TX 78234
6/2001-1/2003 Post-doc fellow, Dept. of Physiology and Nutrition, Case Western Reserve University, Cleveland, OH 44122
1/1999-5/2001 Post-doc fellow, Metabolism unit, Shriners Burns Hospital, Galveston, TX 77550
1/1995-12/1998 Graduate student, the University of Texas Medical Branch, Galveston, TX 77555

HONORS
1. Graduate student Research Award from American Society for Nutritional Science, in recognition of an outstanding paper of Original Research, 1998.
2. The Caroline tum Sudden/ Frances A. Hellebrandt Professional Opportunity Award from the American Physiology Society for research in “Lung Surfactant Kinetics in Conscious Pigs”, 1998
3. The Caroline tum Sudden/ Frances A. Hellebrandt Professional Opportunity Award from the American Physiology Society for research in “Dietary effects on Surfactant Composition and Pulmonary Function”, 1999
4. N.I.H. (HL-007653), Research Fellowship
5. Invited speaker of “Alterations in Coagulation Process Induced by Acidosis, Hypothermia, and Hemorrhage”. Invited speech by the Defense Research and Development of Canada, Toronto, 2003.
6. The Best Manuscript award at the17th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2004.
7. Invited moderator of Scientific Session III & IV Alexander Competition at 18th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2005.
8. The Best Manuscript award at the19th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2006.
9. Invited moderator of Scientific Session III & IV Alexander Competition at 20th annual meeting of the Eastern Association for the Surgery of Trauma, Jan 2007.
10. Invited Chair of Coagulation Management session at the 3rd International Coagulation Course- Management of peri-opreative bleeding complications, Vienna, Austria, April 11-12, 2008
11. Invited plenary speaker at the Plenary session of “Multiple Injury and Coagulation” at the International SHOCK Congress, Cologne, Germany, 28 June – 2 July, 2008
12. Invited speaker at the international meeting of “Epidemiology, Mechanisms, Diagnosis and treatment of early coagulopathy following traumatic injury: Current state of Art”, Chicago, USA, 11-13-July, 2008.
13. Invited moderator at the 8th World Congress on Trauma, Shock, Inflammation, and Sepsis 2010, March 9-13, Munich, Germany.
14. Invited speaker at the session of “Coagulation Function and Resuscitation after Hemorrhage” at the 8th World Congress on Trauma, Shock, Inflammation, and Sepsis 2010, March 9-13, Munich, Germany.
15. Invited discussant of the Trans-Agency Coagulopathy in Trauma workshop by National Institute of Health, April 5-6, 2010, Bethesda, MD.
16. Editorial consultant for American College of Physicians, Physician’s Information and Education Resources, since 2008 to present.

PUBLICATIONS
1) Review articles:
1. Martini WZ. Fibrinogen and Trauma. Review article, MEDIMOND International Proceedings, 2008; 1-5.
2. Martini WZ. Coagulopathy by hypothermia and acidosis: Mechanisms of thrombin generation and fibrinogen availability. Review Article. J Trauma 2009 July, 67(1):202-8; discussion and editorial 208-9.
3. Martini WZ. Fibrinogen metabolic responses to trauma. Review Article. Scand J Trauma Resusc Emerg Med. 2009 Jan 13; 17(1):2-7.
4. Dietmar F and Martini WZ. The role of fibrinogen in trauma induced coagulopathy. Review article, British Journal of Anaesthesia 2010, in press.

2) Original papers:
5. Martini WZ, Chinkes DL, Barrow RE, Murphey ED, and Wolfe RR. Lung Surfactant Kinetics in Conscious Pigs. Am J of Physiol. 277: E187-95, 1999.
6. Martini WZ, Irtun O, Chinkes DL, Barrow RE, and Wolfe RR. Glucose effects on lung surfactant kinetics in conscious pigs. Am. J. Physiol. 279:E920-926, 2000.
7. Wolfe RR and Martini WZ. Changes in intermediary metabolism in severe surgical illness. World Journal of Surgery. 24:639-647, 2000.
8. Martini WZ, Irtun O, Chinkes DL, Barrow RE, and Wolfe RR. Surfactant phosphatidylcholine in thermally injured pigs. Critical Care Medicine. 29:1417-1422, 2001.
9. Irtun O, Martini WZ, Ozkan O, and Wolfe RR. Caval backflow – a potential problem during blood sampling from the hepatic vein. Metabolism. 50:189-193, 2001.
10. Martini WZ, Irtun O, Chinkes DL, Rasmussen B, Traber DL, and Wolfe RR. Alteration of Hepatic Fatty acid Metabolism after burn injury in Pigs. Journal of Parenteral and Enteral Nutrition. 25:310-316, 2001.
11. Wolfe RR, Martini WZ, Irtun O, Hawkins HK, and Barrow RE. Dietary fat composition alters pulmonary function in pigs. Nutrition. 18:647-653, 2002.
12. Kasumov T, Martini WZ, Reszko AE, Bian F, Piece BA, David F, Roe CR, and Brunengraber H. Assay of the concentration and 13C isotopic enrichment of propionyl-CoA, methylmalonyl-CoA, and Succinyl-CoA by Gas Chromatography- Mass Spectrometry. Analytical Biochemistry. 305:90-96, 2002.
13. Martini WZ, Stanley WC, Huang H, Rosier CD, Hoppel CL, and Brunengraber H. Quantitative assessment of anaplerosis of propionate in pig heart in vivo. AJP, 284: E351-356, 2003.
14. Martini WZ, Chinkes DL, and Wolfe RR. Quantification of DNA synthesis from different pathways in cultured fibroblasts and myocytes. Metabolism 2004, 53:128-133.
15. Martini WZ, Chinkes DL, and Wolfe RR. The intracellular free amino acid pool represents precursor enrichment for protein synthesis in cultured fibroblasts and myocytes. Journal of Nutrition. 2004, 134: 1546-1550.
16. Zhang, XJ, Chinkes DL, Wu Z, Martini WZ, and Wolfe RR. Measurements of DNA and protein metabolism in intact skin. Journal of Nutrition. 2004, 134: 2401-2406.
17. Chandler MP, Kerner J, Huang H, Vasquez E, Reszko A, Martini WZ, Brunengraber H, Hoppel CL, Imai M, Rastogi S, Sabbah HN, and Stanley WC. Moderate Severity Heart Failure Does Not Involve a Down-Regulation of Myocardial Fatty Acid Oxidation. AJP: Heart and Circulatory Physiology, 2004, 287:H1538-1543.
18. Martini WZ, Pusateri AE, Uscilowicz JM, Delgado AV, and Holcomb JB. Independent Contributions of Hypothermia and acidosis to Coagulopathy in Swine. Journal of Trauma. 2005, 58:1002-1010.
19. Martini WZ, Chinkes DL, Pusateri AE, Holcomb JB, Yu YM, Zhang XJ, and Wolfe RR. Acute Changes in Fibrinogen Metabolism and Coagulation after Hemorrhage in Pigs. Am J of Physiol 2005, 289: E930-934.
20. Okere IC, McElfresh TA, Brunengraber DZ, Martini WZ, Sterk J, Huang H, Chandler MP, Brunengraber H, and Stanley WC. Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia/reperfusion. J Appl Physiol 2005 Sep 1 (Epub ahead of print)
21. Martini WZ, Dubick MA, Pusateri AE, Park MS, Ryan KL, Holcomb JB. Does bicarbonate correct coagulation function impaired by acidosis in swine? J Trauma 2006, 61:99-106.
22. Martini WZ, Chinkes DL, Sondeen J, and Dubick MA. Effects of hemorrhage and Lactated Ringer’s resuscitation on coagulation and fibrinogen metabolism in swine. SHOCK 2006, 26:396-401.
23. Martini WZ. Effects of hypothermia on fibrinogen metabolism and coagulation function. Metabolism 2007, 56:214-221.
24. Martini WZ, Dubick MA, Wade CE, and Holcomb JB. Evaluation of tris-hydroxymethylaminomethane (THAM) on reversing coagulation abnormalities caused by acidosis in pigs. Crit Care Med. 2007, June, 35 (6): 1568-74.
25. Martini WZ and Holcomb JB. Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and degradation in pigs. Ann Surg. 2007, Nov; 246:831-835.
26. Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma. 2008 Feb; 64(2 Suppl):S79-S85. Discussion S 85.
27. Park MS, Salinas J, Wade CE, Wang JJ, Martini WZ, Pusateri AE, Merrill GA, Chung KK, Wolf SE, Holcomb JB. Combining Early Coagulation and Inflammatory Status Improves Prediction of Mortality in Burned and Nonburned Trauma Patients. J Trauma. 2008 Feb;64(2 Suppl):S188-S194.
28. Martini WZ, Cortez DS, Dubick MA, Park MS, Holcomb JB TEG is Better than PT, aPTT and ACT in Detecting Clinically Relevant Clotting Abnormalities after Hypothermia, Hemorrhagic Shock and Resuscitation in Pigs. J Trauma, 2008;65:535-543.
29. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, Pusateri AE, Wang JJ, Wolf SE, Mann KG, Holcomb JB. Thromboelastography is superior to PT/PTT for the assessment of hypercoagulability and fibrinolysis after injury in burned vs. trauma patients. J Trauma. 2009 Aug, 67:266-75; discussion 275-6.
30. Martini WZ, Wolf SE, Chinkes DL, Chung KK, Dubick MA, Blackbourne L, Yu YM. Enhanced albumin synthesis in severely burned adults. SHOCK, 2010, Feb [Epub ahead of print]